Muse..

Neuron Network Goes Awry, and Brain Becomes an IPod

By CARL ZIMMER
Published: July 12, 2005

Seven years ago Reginald King was lying in a hospital bed recovering from bypass surgery when he first heard the music.

It began with a pop tune, and others followed. Mr. King heard everything from cabaret songs to Christmas carols. "I asked the nurses if they could hear the music, and they said no," said Mr. King, a retired sales manager in Cardiff, Wales.

"I got so frustrated," he said. "They didn't know what I was talking about and said it must be something wrong with my head. And it's been like that ever since."

Each day, the music returns. "They're all songs I've heard during my lifetime," said Mr. King, 83. "One would come on, and then it would run into another one, and that's how it goes on in my head. It's driving me bonkers, to be quite honest."

Last year, Mr. King was referred to Dr. Victor Aziz, a psychiatrist at St. Cadoc's Hospital in Wales. Dr. Aziz explained to him that there was a name for his experience: musical hallucinations.

Dr. Aziz belongs to a small circle of psychiatrists and neurologists who are investigating this condition. They suspect that the hallucinations experienced by Mr. King and others are a result of malfunctioning brain networks that normally allow us to perceive music.

They also suspect that many cases of musical hallucinations go undiagnosed.

"You just need to look for it," Dr. Aziz said. And based on his studies of the hallucinations, he suspects that in the next few decades, they will be far more common.

Musical hallucinations were invading people's minds long before they were recognized as a medical condition. "Plenty of musical composers have had musical hallucinations," Dr. Aziz said.

Toward the end of his life, for instance, Robert Schumann wrote down the music he hallucinated; legend has it that he said he was taking dictation from Schubert's ghost.

While doctors have known about musical hallucinations for over a century, they have rarely studied it systematically. That has changed in recent years. In the July issue of the journal Psychopathology, Dr. Aziz and his colleague Dr. Nick Warner will publish an analysis of 30 cases of musical hallucination they have seen over 15 years in South Wales. It is the largest case-series ever published for musical hallucinations.

"We were trying to collect as much information about their day-to-day lives as we could," Dr. Aziz said. "We were asking a lot of the questions that weren't answered in previous research. What do they hear, for example? Is it nearby or is it at a long distance?"

Dr. Aziz and Dr. Warner found that in two-thirds of the cases, musical hallucinations were the only mental disturbance experienced by the patients. A third were deaf or hard of hearing. Women tended to suffer musical hallucinations more than men, and the average patient was 78 years old.

Mr. King's experience was typical for people experiencing musical hallucinations. Patients reported hearing a wide variety of songs, among them "Don't Cry for Me Argentina" and "Three Blind Mice."

In two-thirds of the cases, the music was religious; six people reporting hearing the hymn "Abide With Me."

Dr. Aziz believes that people tend to hear songs they have heard repeatedly or that are emotionally significant to them. "There is a meaning behind these things," he said.

His study also shows that these hallucinations are different from the auditory hallucinations of people with schizophrenia. Such people often hear inner voices. Patients like Mr. King hear only music.

The results support recent work by neuroscientists indicating that our brains use special networks of neurons to perceive music. When sounds first enter the brain, they activate a region near the ears called the primary auditory cortex that starts processing sounds at their most basic level. The auditory cortex then passes on signals of its own to other regions, which can recognize more complex features of music, like rhythm, key changes and melody.

Neuroscientists have been able to identify some of these regions with brain scans, and to compare the way people respond to musical and nonmusical sounds.